First, from the beginning of v 1 - Timothy's ministry work was beneath the watchful eye of both the Father and the Son.
Second, from the end of v 1 - Timothy's ministry (including his preaching) will be judged by Christ when His kingdom is fully come at His Second Advent.
Third, from v 2 - Paul exhorted Timothy to preach the whole Word of God despite the painful ways that it may affect people.
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