Most conservative Bible scholars believe verses 20-22 have been completely fulfilled in history. The sticking points of disagreement occur with verse 23 and following. In my opinion, verses 23-25 could represent a near/far view. The near fulfillment sees Antiochus IV as the historical persecutor as in vv 9-14 (MacArthur). Antiochus as king in 164 BC was "in the latter period of their rule." Rome conquered Greece in 146 BC and Antiochus died "broken without human agency" from insanity and disease of the bowels.
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Dr. Fred has written numerous books and articles that cover a wide-range of theological topics and he endeavors to present the study of God's Word in a clear fashion, helping the average layperson comprehend the great truths of Scripture.