Resistance to the truth has been the lot of human history.Timothy and God's people throughout "the last days" are urged to be faithful and persevering. Cunning tempters and temptresses seek to invade our homes and re-direct our minds from the truth. If successful, the soul is lost in "folly", that's mindlessness and madness. This poor soul is without hope and without God in this world and the next. From this and these, believers must "turn away".